Biochemical pharmacology (2014). Limei Wang, Birgit Waltenberger, Eva-Maria Pferschy-Wenzig, Martina Blunder, Xin Liu, Clemens Malainer, Tina Blazevic, Stefan Schwaiger, Judith M Rollinger, Elke H Heiss, Daniela Schuster, Brigitte Kopp, Rudolf Bauer, Hermann Stuppner, Verena M Dirsch, Atanas G Atanasov et al. Agonists of the nuclear receptor PPARγ are therapeutically used to combat hyperglycaemia associated with the metabolic syndrome and type 2 diabetes. In spite of being effective in normalization of blood glucose levels, the currently used PPARγ agonists from the thiazolidinedione type have serious side effects, making the discovery of novel ligands highly relevant. Natural products have proven historically to be a promising pool of structures for drug discovery, and a significant research effort has recently been undertaken to explore the PPARγ-activating potential of a wide range of natural products originating from traditionally used medicinal plants or dietary sources. The... - Mr. Gunn