Alterants] http://en.wikipedia.org/wiki/Ca

Thomas Page

Alterants] http://en.wikipedia.org/wiki... , http://en.wikipedia.org/wiki... , http://en.wikipedia.org/wiki... , Pharmacology - Wikipedia, the free encyclopedia - http://en.wikipedia.org/wiki...

Mar 4, 2011 from

http://en.wikipedia.org/wiki... , 3 -21 sort http://en.wikipedia.org/wiki... - Thomas Page

http://en.wikipedia.org/wiki... , 9 -16 polypill http://en.wikipedia.org/wiki... ? - Thomas Page

http://en.wikipedia.org/wiki... [ 11 -18 http://en.wikipedia.org/wiki... 1 -12 The Good Drug Guide http://www.biopsychiatry.com/ [[[[[[ 12 -5 sort sort sort Prozac Nation ... Implications of ? Calvinistic Ect? - Thomas Page

http://en.wikipedia.org/wiki... http://en.wikipedia.org/wiki... http://en.wikipedia.org/wiki... http://en.wikipedia.org/wiki... http://en.wikipedia.org/wiki... Clinical significance In 2008 it was observed that caffeine suppresses activity of human TRPA1, but it was found that mouse TRPA1 channels expressed in sensory neurons cause an aversion to drinking caffeine-containing water, suggesting they mediate the perception of caffeine.[15] TRPA1 has also been implicated in causing the skin irritation experienced by some smokers who are trying to quit by using nicotine replacement therapies such as inhalers, sprays or patches.[7] A missense mutation of TRPA1 was found to be the cause of a hereditary episodic pain syndrome. A family from Colombia suffers from "debilitating upper body pain starting in infancy" which is "usually triggered by fasting or fatigue (illness, cold temperature, and physical exertion being contributory factors)". A gain-of-function mutation in the fourth transmembrane domain causes the channel to be overly sensitive to pharmacological activation.[16] Metabolites of paracetamol (acetaminophen) have been demonstrated to activate TRPA1 receptors in the spinal cord of mice, causing an antinociceptive effect. This is suggested as the antinociceptive mechanism for paracetamol.[17] [edit]Ligand binding Activation of the TRPA1 ion channel by the olive oil phenolic compound oleocanthal appears to be responsible for the pungent or "peppery" sensation in the back of the throat caused by olive oil.[18][19] Although several nonelectrophilic agents, such as thymol and menthol have been reported as TRPA1 agonists, most of the known activators are electrophilic chemicals which have been shown to activate the TRPA1 receptor via the formation of a reversible covalent bond with cysteine residues present in the ion channel.[20][21] For a broad range of electrophilic agents chemical reactivity in combination with a lipophilicity enabling membrane permeation is crucial to TRPA1 agonistic effect. A dibenz[b,f][1,4]oxazepine derivative substituted by a carboxylic methylester at position 10 is the most potent TRPA1 agonist that has been discovered to date (EC50 = 50 pM).[22] The pyrimidine PF-4840154 is a potent, non covalent inhibitor of both the human (EC50 = 23 nM) and rat (EC50 = 97 nM) TrpA1 channels. This compound elicits nociception in a mouse model through TrpA1 activation. Furthermore PF-4840154 is superior to allyl isothiocyanate, the pungent component of mustard oil, for screening purposes.[8] http://en.wikipedia.org/wiki... http://www.ncbi.nlm.nih.gov/pubmed... http://wiki-pain.org/vhosts... [[ Metabolites of paracetamol (acetaminophen) have been demonstrated to activate TRPA1 receptors in the spinal cord of mice, causing an antinociceptive effect. This is suggested as the antinociceptive mechanism for paracetamol.[17] http://en.wikipedia.org/wiki... http://en.wikipedia.org/wiki... [ 11 -18 http://en.wiktionary.org/wiki... http://en.wikipedia.org/wiki... ? sort http://www.wikigenes.org/e... ? 12 -16 http://www.nature.com/news... - Thomas Page

Pain Management http://en.wikipedia.org/wiki... http://en.wikipedia.org/wiki... http://en.wikipedia.org/wiki... ... [[ http://dept.wofford.edu/neurosc... http://www.academia.edu/2057894... http://www.ncbi.nlm.nih.gov/pubmed... http://en.wikipedia.org/wiki... http://www.theatlantic.com/health... http://science.slashdot.org/story... ]] [[ http://en.wikipedia.org/wiki... http://www.bookmorebrides.com/why-soc... http://www.wikihow.com/Read-Bo... http://en.wikipedia.org/wiki... http://en.wikipedia.org/wiki... http://en.wikipedia.org/wiki... http://www.nature.com/nrn... http://neurocritic.blogspot.com/2012... http://www.ncbi.nlm.nih.gov/pubmed... http://www.nature.com/nrn... http://www.ncbi.nlm.nih.gov/pubmed... http://en.wikipedia.org/wiki... http://www.theatlantic.com/health... ]] [[ best nsaid for overuse bursitis ? http://my.clevelandclinic.org/drugs... http://orthoinfo.aaos.org/topic... http://en.wikipedia.org/wiki... http://www.webmd.com/pain-ma... http://en.wikipedia.org/wiki... http://www.ncbi.nlm.nih.gov/pubmed... http://www.todayinpt.com/ce... http://emedicine.medscape.com/article... http://www.physio-pedia.com/Greater... http://www.musculoskeletalnetwork.com/pain... https://www.clinicalkey.com/topics... ]] [[ http://en.wikipedia.org/wiki... http://en.wikipedia.org/wiki... http://en.wikipedia.org/wiki... ]] [[ Make Drugs the Last Resort for Your Pain Many of those succumbing to prescription drug overdoses started taking the drugs not to get high, but to control pain – often back pain. If you are suffering from pain, I suggest you work with a knowledgeable health care practitioner to determine what's really triggering your pain, and then address the underlying cause. Remember, along with exposing you to sometimes deadly risks, medications only provide symptomatic relief and in no way, shape or form treat the underlying cause of your pain. But you don't need to suffer unnecessarily while you get to the bottom of your pain issues. The following options provide excellent pain relief without any of the health hazards that prescription (and even over-the-counter) painkillers carry: Emotional Freedom Technique (EFT), which is a drug-free approach for pain management of all kinds. EFT borrows from the principles of acupuncture, in that it helps you balance out your subtle energy system. It helps resolve underlying, often subconscious, negative emotions that may be exacerbating your physical pain. By stimulating (tapping) well-established acupuncture points with your fingertips, you re-balance your energy system, which tends to dissipate pain. Astaxanthin: One of the most effective fat-soluble antioxidants known. It has very potent anti-inflammatory properties and in many cases works far more effectively than many anti-inflammatory drugs. Higher doses are typically required and one may need 8 mg or more per day to achieve this benefit. Ginger: This herb has potent anti-inflammatory activity and offers pain relief and stomach-settling properties. Fresh ginger works well steeped in boiling water as a tea or grated into vegetable juice. Curcumin: In a study of osteoarthritis patients, those who added 200 mg of curcumin a day to their treatment plan had reduced pain and increased mobility.10 A past study also found that a turmeric extract composed of curcuminoids blocked inflammatory pathways, effectively preventing the launch of a protein that triggers swelling and pain.11 Boswellia: Also known as boswellin or "Indian frankincense," this herb contains specific active anti-inflammatory ingredients. This is one of my personal favorites as I have seen it work well with many rheumatoid arthritis patients. Krill Oil: The omega-3 fats EPA and DHA contained in krill oil have been found by many animal and clinical studies to have anti-inflammatory properties. Bromelain: This enzyme, found in pineapples, is a natural anti-inflammatory. It can be taken in supplement form but eating fresh pineapple may also be helpful. Cetyl Myristoleate (CMO): This oil, found in fish and dairy butter, acts as a "joint lubricant" and an anti-inflammatory. I have used this for myself to relieve ganglion cysts and a mild annoying carpal tunnel syndrome that pops up when I type too much on non-ergonomic keyboards. I used a topical preparation for this. Evening Primrose, Black Currant and Borage Oils: These contain the essential fatty acid gamma linolenic acid (GLA), which is useful for treating arthritic pain. Cayenne Cream: Also called capsaicin cream, this spice comes from dried hot peppers. It alleviates pain by depleting the body's supply of substance P, a chemical component of nerve cells that transmits pain signals to your brain. Methods such as yoga, acupuncture, meditation,12 hot and cold packs, and even holding hands13 can also result in astonishing pain relief without any drugs ]] [[ sort http://blog.drwhitaker.com/blog... http://eantiinflammatorydrugs.com/tag... http://eantiinflammatorydrugs.com/tag... ]] [[ sort http://en.wikibooks.org/wiki... http://en.wikipedia.org/wiki... http://en.wikipedia.org/wiki... http://en.wikipedia.org/wiki... ]] , [[[[[ 9 -10 http://en.wikipedia.org/wiki... , 11 -9 http://onpoint.wbur.org/2013... 1 -13 http://www.npr.org/blogs... 7 -26 http://fitness.mercola.com/sites... 9 -20 http://en.wikipedia.org/wiki... - Thomas Page

Functional selectivity http://en.wikipedia.org/wiki... [ 11 -16 Loving the free and feelin' spirit Of huggin' a tree when you get near it [[ 11 -20 sort "Draggin' the Line" , Dragging the Gut ? http://en.wikipedia.org/wiki... line one toke over http://www.ask.com/questio... "the line" sort {{ sort https://en.wikipedia.org/wiki... }} [[[ buzzed - pleasantly amused / ... , ... \ ... [[[[ http://www.thefreedictionary.com/amusing http://thesaurus.com/browse... [[[[[ BIS (Behavioral Inhibition System) http://en.wikipedia.org/wiki... two general motivational systems underlie behavior ? http://en.wikipedia.org/wiki... { 12 -1 http://en.wikipedia.org/wiki... http://en.wikipedia.org/wiki... http://www.youtube.com/watch... } {([{([ 11 -25 sort Behavioral Investment Theory[edit] Behavioral Investment Theory (BIT) is proposed as a merger of the selection science of behaviorism with the information science of cognitive neuroscience (notice the parallel with the modern synthesis). BIT posits that the nervous system evolved as an increasingly flexible computational control system that coordinates the behavioral expenditure of energy of the animal as a whole. Expenditure of behavioral energy is theorized to be computed on an investment value system built evolutionarily through natural selection operating on genetic combinations and ontogenetically through behavioral selection operating on neural combinations. As such, the current behavioral investments of the animal are conceptualized as the joint product of the two vectors of phylogeny and ontogeny. A unique element of BIT is that it finds a core of agreement and builds bridges between five brain-behavior paradigms: (1) cognitive science; (2) behavioral science; (3) evolutionary theory and genetics; (4) neuroscience; and (5) cybernetics/systems theory. David C. Geary noted the similarities between his "Motivation-to-Control" hypothesis and Henriques' Behavioral Investment Theory, which were developed independently of each other. Furthermore, Geary suggested that his model "seem[ed] to fill in many of the proximate mechanisms and evolutionary pressures that define the life-mind joint point, and provided a framework for further development of the mind-culture joint point." [18] http://en.wikipedia.org/wiki... - Thomas Page

sort may delete under the influence mixes of fun and tragedy mirth and madness dazed and confused lucky and luckless lack of fear and mixed complex emotions of past self and others observations of a range comic to horrendous tragedy eyes wide open lucky hard knocks learning < rough draft [[[[ recent local changes state liquor stores to now supermarkets lots of slick advertising ??? [[[[[[ overall wastage 4D power of ten ?, constantly changing personal perspective ... - Thomas Page

sort certainty of harm variability from x vulnerabilities [20% of the 20% of the 20% of the 80/20 kind of thing [[ 1 -4 Realities of Drug Use? / “It’s Not to Be Taken Lightly” [[[[[ sort mesocorticolimbic neurotransmission http://www.nature.com/nature... 9 -30 http://www.washingtonpost.com/blogs... - Thomas Page

Pharmacological reality check { Alcohol [ Happy Healthy People [ the why of conforming to folkways? [ lessons from prohibition [ DESIRED OUTCOMES - everybody happy healthy - win win [ alternatives? innovation? [[[ 1 -4 (http://friendfeed.com/citizen... http://friendfeed.com/citizen... ) [[[[[ ? David Brooks > We now have a couple states — Colorado and Washington — that have gone into the business of effectively encouraging drug use. By making weed legal, they are creating a situation in which the price will drop substantially. One RAND study suggests that prices could plummet by up to 90 percent, before taxes and such. As prices drop and legal fears go away, usage is bound to increase. This is simple economics, and it is confirmed by much research. Colorado and Washington, in other words, are producing more users. The people who debate these policy changes usually cite the health risks users would face or the tax revenues the state might realize. Many people these days shy away from talk about the moral status of drug use because that would imply that one sort of life you might choose is better than another sort of life. But, of course, these are the core questions: Laws profoundly mold culture, so what sort of community do we want our laws to nurture? What sort of individuals and behaviors do our governments want to encourage? I’d say that in healthy societies government wants to subtly tip the scale to favor temperate, prudent, self-governing citizenship. In those societies, government subtly encourages the highest pleasures, like enjoying the arts or being in nature, and discourages lesser pleasures, like being stoned. In legalizing weed, citizens of Colorado are, indeed, enhancing individual freedom. But they are also nurturing a moral ecology in which it is a bit harder to be the sort of person most of us want to be. http://www.nytimes.com/2014... ??? On the other hand ... [[[[[[[[[[[[[ 4 -17 http://www.smithsonianmag.com/smart-n... http://www.jneurosci.org/content... http://www.vox.com/2014... 4 -24 http://time.com/72546... - Thomas Page

Signals - [ biochemical effects - transducers ] - signals - [ ] - signals - [] - ... 1 -4 sort examples http://en.wikipedia.org/wiki... http://en.wikipedia.org/wiki... http://en.wikipedia.org/wiki... ... ... ... - Thomas Page

7 - 26 more on pain http://fitness.mercola.com/sites... 9 -25 sort http://en.wikipedia.org/wiki... 1 -15 mental pain - Thomas Page

9 -20 Foods and Pharms side effects and collateral Damage to Wetware , hardware function fluids , ... Unknown unknowns ? Epidemics source unrecognized = new profits opportunities and non liability for side effecting damages ? - Thomas Page

Proton Pump Inhibitor Deficiency Disease ? http://en.wikipedia.org/wiki... Process control of Gastro? [[ 4 -19 kludge therapy? 4 -28 http://articles.mercola.com/sites... 4 -28 http://en.wikipedia.org/wiki... Glucan http://en.wikipedia.org/wiki... http://en.wikipedia.org/wiki... http://en.wikipedia.org/wiki... - Thomas Page

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Glucagon http://en.wikipedia.org/wiki... Flonase ? Flovent http://en.wikipedia.org/wiki... http://en.wikipedia.org/wiki... - Thomas Page

9 -14 Canibinoids http://friendfeed.com/citizen... The cannabinoid HU-210 has been shown to prevent amyloid beta-promoted inflammation.[59] The endocannabinoids anandamide and noladin ether have also been shown to be neuroprotective against amyloid beta in vitro - Thomas Page

9 -14 Alzheimer's_disease http://en.wikipedia.org/wiki... http://en.wikipedia.org/wiki... http://en.wikipedia.org/wiki... , http://www.newrepublic.com/article... http://friendfeed.com/citizen... - Thomas Page

9 -14 Sort Fugitive film http://en.wikipedia.org/wiki... http://www.theonion.com/article... [ http://en.wikipedia.org/wiki... http://en.wikipedia.org/wiki... 9 -17 Provasic RDU-90 http://en.wikipedia.org/wiki... [[[[ http://en.wikipedia.org/wiki... 9 -28 late night infomercial Kevin Trudeau Natural Cures ???? merits of philosophy? - Thomas Page

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12 -6 Cost Recovery of ... And ... And ... [ ... - Thomas Page

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12 -6 sort http://www.npr.org/templat... - Thomas Page

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Santa ... - Thomas Page

2 -9 http://www.newyorker.com/magazin... - Thomas Page

Ergot http://en.wikipedia.org/wiki... Kykeon http://en.wikipedia.org/wiki... [ Beowulf http://en.wikipedia.org/wiki... [[ Symposium http://en.wikipedia.org/wiki... - Thomas Page

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